Kappa Free Light Chain Disease

The disease is more common in men than in women.

Kappa free light chain disease.

The age at which you were diagnosed. Lcs are normally cleared by the kidneys but in lcdd these light chain deposits damage organs and cause disease. These unlinked chains are known as free light chains. Light chain deposition disease lcdd is a rare blood cell disease which is characterized by deposition of fragments of infection fighting immunoglobulins called light chains lcs in the body.

There are two types of light chains. A free light chains test measures the amount of lambda and kappa free light chains in the blood. There are two types of light chains. The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007.

What are light chains. The risk of developing light chain deposition varies significantly depending on the other disease that the patient has. Ninety seven patients with light chain disease lcd were studied. People with lcdd make too many light chains which get deposited in many body tissues while lcdd can occur in any organ the kidneys are always.

Light chain deposition disease nodular glomerulopathy kappa light chain deposition disease. Light chain deposition usually occurs along with another disease affecting the whole body. The level of free light chains another kind of protein in your blood. A lower proportion of kappa lcd patients 15 7 than lambda lcd patients 42 2 died within.

Patients with this disease typically are over the age of 50 and have an average age of 67. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. This means type g immunoglobulin one of the possible types of heavy chain one combination of types of light chain kappa or lambda. Igm ige and igd types have one much lower incidence.

65 of patients with myeloma have an igg type. Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia. Light chain deposition disease lcdd is a rare condition characterized by the deposition of specific proteins monoclonal light chains in the kidneys and other organs light chains are used to make antibodies that the body needs to fight infection. In general the higher the free light chains the more aggressive the disease is.

The kidneys are almost always affected and this often leads to kidney failure. Herrera ga joseph l gu x hough a barlogie b. Therefore the serum free light chain test is a better predictor of outcome than the amount of m protein in the blood. Lambda and kappa light chains.